Dietary Pyridoxine Controls Efficacy of Vitamin B 6 -Auxotrophic Tuberculosis Vaccine Bacillus Calmette-Guérin Δ ureC :: hly Δ pdx1 in Mice
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Dietary Pyridoxine Controls Efficacy of Vitamin B6-Auxotrophic Tuberculosis Vaccine Bacillus Calmette-Guérin ΔureC::hly Δpdx1 in Mice
UNLABELLED The only tuberculosis (TB) vaccine in use today, bacillus Calmette-Guérin (BCG), provides insufficient protection and can cause adverse events in immunocompromised individuals, such as BCGosis in HIV(+) newborns. We previously reported improved preclinical efficacy and safety of the recombinant vaccine candidate BCG ΔureC::hly, which secretes the pore-forming listeriolysin O of Liste...
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BACKGROUND Bovine tuberculosis (TB) is a zoonotic disease caused by Mycobacterium bovis, responsible for causing major losses in livestock. A cost effective alternative to control the disease could be herd vaccination. The bacillus Calmette-Guérin (BCG) vaccine has a limited efficacy against bovine TB, but can improved by over-expression of protective antigens. The M. bovis antigen 85B demonstr...
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ژورنال
عنوان ژورنال: mBio
سال: 2014
ISSN: 2161-2129,2150-7511
DOI: 10.1128/mbio.01262-14